Generic: Spironolactone 50mg/ Furosemide 40mg.

Brand: Frusin Plus ®40

What is Frusin Plus 40.

Frusin Plus 40 is a combination medicine used in the treatment of resistant edema associated with secondary hyperaldosteronism, resistant hypertension, chronic cardiac failure, and hepatic cirrhosis. This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Frusin Plus 40 tablet

Low magnesium levels, decreased calcium level, Hearing impairment, Headache, weakness, increased sensitivity of the skin to sunlight, muscle spasm, Skin rash, stomach pain, dizziness, irregular heartbeat

What is it prescribed for?

Resistant Hypertension

Chronic cardiac failure

Resistant edema associated with secondary Hyperaldosteronism

Hepatic cirrhosis

How long does it take for this medicine to take effect?

The effect of this medicine can be observed within 30 to 60 minutes of administration of the dose.

How long do the effects of this medicine last?

The effect of this medicine lasts for an average duration of 2 to 3 days.

Is it safe to consume alcohol while taking this medicine?

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.

Is this a habit forming medicine?

No habit forming tendency has been reported.

Can this medicine be taken during pregnancy?

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Can this medicine be taken while breast-feeding?

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

When not to use?

This medicine is not recommended for use in patients with a known allergy to spironolactone, furosemide, other diuretics, or any other inactive ingredients present with the formulation.

Anuria

This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.

Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

General Warnings

Volume depletion and Electrolyte imbalance

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperkalemia

This medicine may increase the potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine.

Diabetes

This medicine should be used with extreme caution in patients with diabetes mellitus due to the increased risk of severe adverse effects. Close monitoring of blood glucose levels and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in elderly patients

This medicine should be used with caution in elderly patients due to the increased risk of severe adverse effects. Appropriate dose adjustments may be necessary based on the clinical condition.

Severe kidney impairment

This medicine is not recommended for use in patients with a known history of severe kidney impairment due to the increased risk of worsening of the patient’s condition.

Driving or operating machines

This medicine may cause dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any dizziness during treatment with this medicine.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Dispensing Note

Take this medicine as advised by your Pharmacist. Do not take in larger amounts than prescribed. It is advised to take this medicine in the daytime to prevent sleep disturbance. Drink an adequate amount of water. Close monitoring of kidney function and electrolytes levels is necessary during treatment with this medicine. Report any undesired side effects to the pharmacist or doctor. Do not stop the use of this medicine without consulting your pharmacist or doctor.